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2 edition of Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions found in the catalog.

Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions

Larry Wayne Hall

Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions

by Larry Wayne Hall

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  • 31 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 99 leaves
Number of Pages99
ID Numbers
Open LibraryOL21081195M

commonly used to increase dissolution rate and thereby oral absorption and bioavailability of low water soluble drugs, there is practical limitation to these techniques. Among numerous ways of enhancing drug dissolution solid dispersion of drug in a water soluble polymer is one of the promising technique5. Solid dispersion (SD) is defined as. CHAPTER 9 BIBLIOGRAPHY BIBLIOGRAPHY 1. Goldberg A., Gibaldi M. and Kanig L.: Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II experimental evaluation of a solid dispersions of griseofulvin, J. Pharm. Sci., ; pp

Pharmaceutical Solid Dispersion Technology. Muhammad J. Habib Methods of Preparing Solid Dispersions. piroxicam polyethylene glycol polymers polyvinylpyrrolidone poorly water-soluble drugs powder precipitation properties rate of dissolution ratio reduced release of drugs Sekikawa solid dispersion systems solid solution solvate Reviews: 2. The purpose of this study was to prepare solid dispersion by Kneading method, to improve the dissolution rate of Mesalamine. It was postulated that, if the drug is only slightly soluble in water, the dissolution process could be the rate-limiting step in the absorption of drug thus resulting in poor bioavailability.

Invasive antifungal infections are reasons for morbidity and mortality in immunogenic patients worldwide. Posaconazole is a most promising antifungal agent against all types of invasive infections with high % of cure rate. The marketed suspension formulation has low bioavailability and is needed to be taken with food. In this paper, PCZ hot melt extruded amorphous solid Cited by: The main purpose of this research was to study the mechanism of drug release from solid dispersions of albendazole, giving special emphasis to particle size of the drug in solid dispersions. Solid dispersions were prepared using three different carriers, mixing ratios and methods in an attempt to improve the solubility and dissolution rate of.


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Dissolution rate and absorption studies of griseofulvin from solid polymer dispersions by Larry Wayne Hall Download PDF EPUB FB2

Abstract. A ground mixture of griseofulvin and microcrystalline cellulose was prepared by grinding them in a vibrational ball mill. The dissolution rate and bioavailability of griseofulvin from the ground mixture were shown to be significantly greater than those from a micronized griseofulvin by: A marked increase of the dissolution rate and solubility of griseofulvin contained in these solid dispersions was observed compared with that of drug.

Other approach include shielding the drug from the gastric metabolism and targeted drug release to obtain optimal drug absorption. In this study, a poorly water-soluble model drug, griseofulvin, was encapsulated as disordered solid dispersions into Eudragit L enteric polymer micromatrix particles, which were produced by by: In this study, a poorly water-soluble model drug griseofulvin was encapsulated as disordered solid dispersions into Eudragit® L enteric polymer.

In this study, the supersaturation behavior of griseofulvin (GF) was investigated, followed by investigation of the dissolution and oral absorption behaviors of GF ASDs with an emphasis on the degree of supersaturation. Materials and methods Materials. Griseofulvin (GF) was purchased from Fuji Film Wako Pure Chemicals (Osaka, Japan).Author: Kohsaku Kawakami, Kyosuke Suzuki, Masafumi Fukiage, Maki Matsuda, Yohei Nishida, Michinori Oikawa, T.

Win Loung Chiou and Sarfaraz Niazi, Phase diagram and dissolution‐rate studies on sulfathiazole‐urea solid dispersions, Journal of Pharmaceutical Sciences, 60, 9, (), (). Wiley Online LibraryCited by: The dissolution rate of GF from HPMCAS solid dispersions was studied.

The results showed higher dissolution rate of drug from the solid dispersions. About 90% of GF was dissolved within the first 15 min of the by:   Dissolution case studies of weak base, weak acid, and neutral compounds are presented, illustrating a rational approach for the development and implementation of the desired dissolution characteristics for the amorphous drug product performance.

Oral absorption of griseofulvin in dogs: increased absorption via solid dispersion in Cited by: New Method of Solid-state Dispersion for Increasing Dissolution Rates Sir: The authors have recently reported on the potential vallue of solid-state dispersion, viz., solid solutions, in enhancing the dissolution rate and gastrointestinal absorption of drugs ().

Amorphous solid dispersions are used as a strategy to improve the bioavailability of poorly water-soluble compounds. When formulating with a polymer, it is important not only for the polymer to stabilize against crystallization in the solid state, but also to improve the dissolution profile through inhibiting crystallization from the supersaturated solution generated by dissolution Cited by:   Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry.

• Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems •. Griseofulvin is deposited in keratin precursor cells within 4–8 hr of administration PO.

Sweat and transdermal fluid loss appear to play an important role in griseofulvin transfer in the stratum corneum. When these cells differentiate, griseofulvin remains bound and persists in keratin, making it resistant to fungal invasion.

For this reason, new growth of hair, nails, or horn is the. The objective of this study was to prepare solid dispersions by fusion and co-precipitation and evaluate, in vitro, the influence of these preparations of PZQ on solubility, dissolution rate, and intestinal absorption.

MATERIAL AND METHODS. Praziquantel (PZQ) was obtained with a purity of %, from Induken Quimica Ltda (Brazil). The specifically designed in-vivo dissolution study will be required in solid dispersion system to access the absorption rate, and hence its bioavailability and to demonstrate the bioequivalence ultimately.

Advantages of Solid Dispersions: Improving drug bioavailability by changing their water solubility has been possible by solid dispersion. Dissolution Studies. Dissolution studies were carried out in USP Apparatus II (VKVankel Industries, Cary, NC) at rpm in ml deionized water (pH ) at 37°C (n = 6).The apparatus was equipped with an eight channel peristaltic pump and a UV spectrophotometer for determination of the drug concentration and for return of sample to the dissolution by: Clonazepam is an anticonvulsant and anxiolytic drug characterized by poor solubility and rapid absorption.

The purpose of the study was to improve the solubility of clonazepam in solid dispersions by incorporating hydroxypropyl methyl cellulose (HPMC) and poloxamer The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited.

For this reason, the production of amorphous drugs with adequate stability remains a major challenge and formulation strategies based on solid Cited by: From the dissolution study it was observed that only 26% of the drug was released after 2 h from the pure EFV sample. In comparison to this the dissolution rates of all the solid dispersions were remarkably enhanced (Prate from solid dispersions can be due to several reasons.

rate limiting step in the process of absorption. In such case, we can improve their solubility and dissolution rate. To study the effect of surfactant on the solid dispersion of poorly water soluble drug.

Keywords: Solubilisation, solid dispersion, Polyehylene Glycol, bioavailability, dissolution rate etc. INTRODUCTIONFile Size: KB. Solid dispersion (SD), wherein one or more poorly soluble drugs are dispersed in hydrophilic polymers, is an effective method for improving the solubility and bioavailability of poorly soluble compounds [30,31,32].Hydrophilic polymer properties determine drug dissolution capacities [].SD polymers [34,35,36,37,38,39], such as polyethylene glycol, polyvinylalcohol, cellulose Cited by: 3.

It has been reported that 40% of the marketed products and up to 70% of the new chemical entities (NCE) are poorly water-soluble [1]. Intestinal absorption of these drugs turns out to be rate-limiting due to the poor aqueous solubility, which resulted in low bioavailability.Griseofulvin, Indomethacin and Oxazepam.

The ability of solid dispersions to afford drug release as fine, dispersed particles has resulted in improvements in dissolution rates of poorly water soluble drugs which have also been reflected in increases in oral bioavailability[3].

The increase in dissolution rate and solubility provided by solid.Applications of solid dispersions Bindu Yadav 1* and Y. S. Tanwar 2 therefore increases the dissolution rate and absorption of drugs.

drug crystallizes from drug-polymer miscible mixture is greater than the rate at which drug-polymer fluid mixture solidifies.

(c) Amorphous Solid dispersion: If the drug-polymer fluid mixture is cooled at.